To drive the display, you will need 3 to 5 digital output pins (depending on whether you want to manually control the chip select and reset lines). Another pin can be used to control (via on/off or PWM) the backlight. To make things easy for you, we've written a nice graphics library that can print text, pixels, rectangles, circles and lines! The library is written for the Arduino but can easily be ported to your favorite microcontroller.
You can pick up one of these displays at the adafruit shop!