Your board will most likely have vias and through holes for part components.  Now is the time to drill holes through the board.  I picked up this 20 piece set of Carbide Rotary Micro bits from a local Harbor Freight.  http://www.harborfreight.com/20-pc-carbide-rotary-micro-bit-assorted-set-62379.html  For double sided boards, place bare wire through the vias (holes connecting the top and bottom layer) and solder on both sides.