There's a few oddities when running Blinka/CircuitPython on linux. Here's a list of stuff to watch for that we know of!
Mixed SPI mode devices
Due to the way we share an SPI peripheral, you cannot have two SPI devices with different 'mode/polarity' on the same SPI bus - you'll get weird data
95% of SPI devices are mode 0, check the driver to see mode or polarity settings. For example:
Not all peripherals supported
Some CircuitPython modules like neopixel, analogio, audioio and pulseio may not be supported. We aim to have, at a minimum, digitalio and busio (i2c/SPI). This lets you use the vast number of driver libraries
Some libraries, like Adafruit_CircuitPython_DHT will try to bit-bang if pulsein isn't available. Slow linux boards (<700MHz) may not be able to read the pins fast enough), you'll just have to try!