You may want to get winetricks in order to adjust some settings:

sudo apt install cabextract
wget https://raw.githubusercontent.com/Winetricks/winetricks/master/src/winetricks
sudo chmod +x winetricks && sudo mv winetricks /usr/local/bin/

With this you can change the renderer, sound driver, etc. When running it, you need to suppress the box86 banner with BOX86_NOBANNER=1. Then you can install some fonts:

BOX86_NOBANNER=1 winetricks corefonts

You can also run winetricks without any arguments and it will present a menu full of possibilities. Explore and see what's there, or just click Cancel until it exits.

You can change the DirectDraw renderer if something isn't working well:

BOX86_NOBANNER=1 winetricks renderer=gdi

That will set it to GDI and might work better with some programs. Setting renderer=gl will usually perform better. Check this list of arguments for everything you can do.

Now what? Why run Windows programs? Well...

How about another classic?

Starcraft running on a Raspberry Pi!

You could do practical things as well, like replace an ancient system running old business software with a modern, tiny, cheap system that can run the same thing.

Some things will segfault when starting but after trying another time or two they run fine. You may need to adjust settings in WINE or use different command line arguments for the program you're trying to run.

Check the compatibility list for things tagged with Wine to see if someone else has found a way to run it.