We tried to make this TFT breakout useful for both high-pin microcontrollers that can handle 8-bit data transfer modes as well as low-pincount micros like the Arduino UNO and Leonardo that are OK with SPI.

Essentially, the tradeoff is pins for speed. SPI is about 2-4 times slower than 8-bit mode, but that may not matter for basic graphics!

In addition, SPI mode has the benefit of being able to use the onboard microSD card socket for reading images. We don't have support for this in 8-bit mode so if you want to have an all-in-one image viewer type application, use SPI!